[
  {
    "question_passport_id": "ICIDM-UNASKED-001",
    "status": "CANDIDATE_UNASKED",
    "origin": "2231-publication corpus self-observation",
    "gap_type": "RELATIONSHIP_SPARSE",
    "question": "Why is the Cryptococcus × Whole-genome sequencing relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
    "observational_basis": {
      "gap_type": "RELATIONSHIP_SPARSE",
      "pathogen": "Cryptococcus",
      "technology": "Whole-genome sequencing",
      "observed_publications": 0,
      "pathogen_population": 100,
      "technology_population": 185,
      "score": 285.0,
      "question": "Why is the Cryptococcus × Whole-genome sequencing relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
      "reality_return": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted.",
      "boundary": "Publication sparsity does not imply scientific absence or institutional incapability."
    },
    "evidence_boundary": "Publication sparsity does not imply scientific absence or institutional incapability.",
    "review_gate": "HI review required before research prioritisation",
    "next_action": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted."
  },
  {
    "question_passport_id": "ICIDM-UNASKED-002",
    "status": "CANDIDATE_UNASKED",
    "origin": "2231-publication corpus self-observation",
    "gap_type": "RELATIONSHIP_SPARSE",
    "question": "Why is the Arboviruses × Clinical trial / therapy relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
    "observational_basis": {
      "gap_type": "RELATIONSHIP_SPARSE",
      "pathogen": "Arboviruses",
      "technology": "Clinical trial / therapy",
      "observed_publications": 0,
      "pathogen_population": 43,
      "technology_population": 215,
      "score": 258.0,
      "question": "Why is the Arboviruses × Clinical trial / therapy relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
      "reality_return": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted.",
      "boundary": "Publication sparsity does not imply scientific absence or institutional incapability."
    },
    "evidence_boundary": "Publication sparsity does not imply scientific absence or institutional incapability.",
    "review_gate": "HI review required before research prioritisation",
    "next_action": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted."
  },
  {
    "question_passport_id": "ICIDM-UNASKED-003",
    "status": "CANDIDATE_UNASKED",
    "origin": "2231-publication corpus self-observation",
    "gap_type": "RELATIONSHIP_SPARSE",
    "question": "Why is the Aspergillus × Whole-genome sequencing relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
    "observational_basis": {
      "gap_type": "RELATIONSHIP_SPARSE",
      "pathogen": "Aspergillus",
      "technology": "Whole-genome sequencing",
      "observed_publications": 0,
      "pathogen_population": 29,
      "technology_population": 185,
      "score": 214.0,
      "question": "Why is the Aspergillus × Whole-genome sequencing relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
      "reality_return": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted.",
      "boundary": "Publication sparsity does not imply scientific absence or institutional incapability."
    },
    "evidence_boundary": "Publication sparsity does not imply scientific absence or institutional incapability.",
    "review_gate": "HI review required before research prioritisation",
    "next_action": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted."
  },
  {
    "question_passport_id": "ICIDM-UNASKED-004",
    "status": "CANDIDATE_UNASKED",
    "origin": "2231-publication corpus self-observation",
    "gap_type": "RELATIONSHIP_SPARSE",
    "question": "Why is the Staphylococcus aureus / MRSA × Serology / immunology relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
    "observational_basis": {
      "gap_type": "RELATIONSHIP_SPARSE",
      "pathogen": "Staphylococcus aureus / MRSA",
      "technology": "Serology / immunology",
      "observed_publications": 0,
      "pathogen_population": 54,
      "technology_population": 126,
      "score": 180.0,
      "question": "Why is the Staphylococcus aureus / MRSA × Serology / immunology relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
      "reality_return": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted.",
      "boundary": "Publication sparsity does not imply scientific absence or institutional incapability."
    },
    "evidence_boundary": "Publication sparsity does not imply scientific absence or institutional incapability.",
    "review_gate": "HI review required before research prioritisation",
    "next_action": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted."
  },
  {
    "question_passport_id": "ICIDM-UNASKED-005",
    "status": "CANDIDATE_UNASKED",
    "origin": "2231-publication corpus self-observation",
    "gap_type": "RELATIONSHIP_SPARSE",
    "question": "Why is the Bordetella pertussis × Clinical trial / therapy relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
    "observational_basis": {
      "gap_type": "RELATIONSHIP_SPARSE",
      "pathogen": "Bordetella pertussis",
      "technology": "Clinical trial / therapy",
      "observed_publications": 1,
      "pathogen_population": 40,
      "technology_population": 215,
      "score": 127.5,
      "question": "Why is the Bordetella pertussis × Clinical trial / therapy relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
      "reality_return": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted.",
      "boundary": "Publication sparsity does not imply scientific absence or institutional incapability."
    },
    "evidence_boundary": "Publication sparsity does not imply scientific absence or institutional incapability.",
    "review_gate": "HI review required before research prioritisation",
    "next_action": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted."
  },
  {
    "question_passport_id": "ICIDM-UNASKED-006",
    "status": "CANDIDATE_UNASKED",
    "origin": "2231-publication corpus self-observation",
    "gap_type": "RELATIONSHIP_SPARSE",
    "question": "Why is the Influenza / respiratory viruses × Whole-genome sequencing relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
    "observational_basis": {
      "gap_type": "RELATIONSHIP_SPARSE",
      "pathogen": "Influenza / respiratory viruses",
      "technology": "Whole-genome sequencing",
      "observed_publications": 2,
      "pathogen_population": 133,
      "technology_population": 185,
      "score": 106.0,
      "question": "Why is the Influenza / respiratory viruses × Whole-genome sequencing relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
      "reality_return": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted.",
      "boundary": "Publication sparsity does not imply scientific absence or institutional incapability."
    },
    "evidence_boundary": "Publication sparsity does not imply scientific absence or institutional incapability.",
    "review_gate": "HI review required before research prioritisation",
    "next_action": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted."
  },
  {
    "question_passport_id": "ICIDM-UNASKED-007",
    "status": "CANDIDATE_UNASKED",
    "origin": "2231-publication corpus self-observation",
    "gap_type": "RELATIONSHIP_SPARSE",
    "question": "Why is the Streptococcus pneumoniae × Bioinformatics / modelling relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
    "observational_basis": {
      "gap_type": "RELATIONSHIP_SPARSE",
      "pathogen": "Streptococcus pneumoniae",
      "technology": "Bioinformatics / modelling",
      "observed_publications": 0,
      "pathogen_population": 48,
      "technology_population": 41,
      "score": 89.0,
      "question": "Why is the Streptococcus pneumoniae × Bioinformatics / modelling relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
      "reality_return": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted.",
      "boundary": "Publication sparsity does not imply scientific absence or institutional incapability."
    },
    "evidence_boundary": "Publication sparsity does not imply scientific absence or institutional incapability.",
    "review_gate": "HI review required before research prioritisation",
    "next_action": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted."
  },
  {
    "question_passport_id": "ICIDM-UNASKED-008",
    "status": "CANDIDATE_UNASKED",
    "origin": "2231-publication corpus self-observation",
    "gap_type": "RELATIONSHIP_SPARSE",
    "question": "Why is the Influenza / respiratory viruses × Bioinformatics / modelling relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
    "observational_basis": {
      "gap_type": "RELATIONSHIP_SPARSE",
      "pathogen": "Influenza / respiratory viruses",
      "technology": "Bioinformatics / modelling",
      "observed_publications": 1,
      "pathogen_population": 133,
      "technology_population": 41,
      "score": 87.0,
      "question": "Why is the Influenza / respiratory viruses × Bioinformatics / modelling relationship sparse in the publication corpus, and is this a true capability gap, a terminology/classification gap, or simply an unrepresented relationship?",
      "reality_return": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted.",
      "boundary": "Publication sparsity does not imply scientific absence or institutional incapability."
    },
    "evidence_boundary": "Publication sparsity does not imply scientific absence or institutional incapability.",
    "review_gate": "HI review required before research prioritisation",
    "next_action": "Review source classifications and institutional history before deciding whether targeted evidence search or a new experiment is warranted."
  },
  {
    "question_passport_id": "ICIDM-UNASKED-009",
    "status": "CANDIDATE_UNASKED",
    "origin": "2231-publication corpus self-observation",
    "gap_type": "STALE_OR_DORMANT",
    "question": "The Streptococcus pneumoniae × PCR / molecular diagnostics relationship was recurrent but has not appeared recently in the corpus. Is the capability obsolete, absorbed into newer methods, dormant, or simply relabelled?",
    "observational_basis": {
      "gap_type": "STALE_OR_DORMANT",
      "pathogen": "Streptococcus pneumoniae",
      "technology": "PCR / molecular diagnostics",
      "observed_publications": 8,
      "last_seen": 2012,
      "first_seen": 2003,
      "score": 29.0,
      "question": "The Streptococcus pneumoniae × PCR / molecular diagnostics relationship was recurrent but has not appeared recently in the corpus. Is the capability obsolete, absorbed into newer methods, dormant, or simply relabelled?",
      "reality_return": "Trace later methods, teams, datasets and capability records before treating the relationship as lost.",
      "boundary": "No recent publication signal does not prove loss of capability."
    },
    "evidence_boundary": "No recent publication signal does not prove loss of capability.",
    "review_gate": "HI review required before research prioritisation",
    "next_action": "Trace later methods, teams, datasets and capability records before treating the relationship as lost."
  }
]